Protposer

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Proposal of potentially stabilizing mutations.

Protposer is a prediction server that, given a PDB structure, proposes a list of point mutations, ordered in decreasing potential of stabilization, based on several structural and sequence features of the protein. Users can provide the PDB structure directly, by uploading it to the server, or using the PDB ID code. Protposer analyzes different features from the structure in order to find weak spots in the structure that may be reinforced upon mutation. Then, those proposed mutations are evaluated for a set of different features in order to estimate their probability of being stabilizing, using a machine learning logistic regression model.

The results are shown in an HTML summary, containing all the proposed mutations, the reason why they are proposed and how they scored for different features. The report is emailed to the address provided by the user.

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